Clustal Omega
Clustal Omega: Open-Source Multiple Sequence Alignment Program
Clustal Omega is an open-source multiple sequence alignment program for proteins and DNA/RNA, aligning large numbers of sequences quickly and accurately with advanced techniques like mBed and HHalign.
What is Clustal Omega?
Clustal Omega is a powerful multiple sequence alignment tool for aligning protein, DNA and RNA sequences. It is open-source and free to use. Clustal Omega uses advanced alignment algorithms like mBed and HHalign to enable the alignment of extremely large numbers (hundreds of thousands to millions) of sequences very quickly with high accuracy.
Some key features of Clustal Omega include:
- Can align protein, DNA and RNA sequences
- Very fast - can align hundreds of thousands of sequences in minutes
- Highly accurate sequence alignments
- Support for alignment of very large sequences
- Easy to use graphical user interface
- Can add sequences to existing alignments
- Generates phylogenetic guide trees
- Offers various output format options like Clustal, FASTA, PHYLIP, etc.
Clustal Omega is used in many sequencing pipelines and workflows that require highly accurate multiple sequence alignments. It is commonly used in fields like evolutionary biology, genomics, molecular biology, phylogenetics and more. The open-source nature also allows advanced users to customize and extend Clustal Omega if needed.
Clustal Omega Features
Features
- Performs multiple sequence alignment of proteins, DNA and RNA
- Uses seeded guide trees and HMM profile-profile techniques for alignment
- Can align large numbers of sequences quickly
- Web server available for online alignment
- Command line version available for bulk sequence alignment
- Built-in graphics for visualization
- Integration with Jalview for alignment editing
Pricing
- Free
- Open Source
Pros
Cons
Official Links
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