ProBIND
ProBIND is a software tool for predicting protein-protein binding sites and characterizing molecular recognition features (MoRFs). It uses sequence and structural information to identify regions likely to be involved in protein interactions.
protein-binding
molecular-recognition
protein-interaction-prediction
ProBIND: Protein-Protein Binding Site Prediction Tool
ProBIND predicts protein-protein binding sites and characterizes molecular recognition features (MoRFs) using sequence and structural information to identify regions likely to be involved in protein interactions.
What is ProBIND?
ProBIND is a software application designed to predict and characterize protein-protein binding sites and interactions. It utilizes advanced computational algorithms and statistical models to identify high probability binding regions based on a protein's amino acid sequence and structural features.
Key capabilities and features of ProBIND include:
- Predicts interfacial residues likely to be involved in protein-protein binding interactions using machine learning models trained on empirical binding data
- Characterizes Molecular Recognition Features (MoRFs) - intrinsically disordered protein regions that undergo disorder-to-order transitions upon binding
- Incorporates evolutionary conservation information to improve binding site predictions
- Provides detailed visualization and analysis of predicted binding sites and MoRF regions on protein structures
- Allows batch analysis and high-throughput annotation of binding sites for entire proteomes
- Web-based interface for easy access along with stand-alone command-line programs
- Free and open-source under the GNU General Public License (GPL)
Overall, ProBIND is a versatile protein-protein interaction analysis tool, enabling detailed functional annotation of binding interfaces, MoRFs, and other key protein-protein contact regions.
ProBIND Features
Features
- Predicts binding sites and MoRFs using sequence information
- Incorporates structural information when available
- Web-based user interface and standalone versions available
- Provides graphical visualization of predictions
- Allows batch predictions on multiple sequences
- Integrates with other bioinformatics resources and pipelines
Pricing
- Free
- Open Source
Pros
Accurate binding site predictions
Fast analysis of large datasets
Intuitive visualization and output
Free web server available
Standalone software allows local installation
Cons
Limited documentation and support
Web interface lacks some advanced options
Standalone version requires command line usage
Does not provide insights into binding mechanisms
Official Links
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