Autopol

Autopol

Autopol is an open-source tool for computer-aided protein engineering and protein design. It allows users to computationally design novel proteins and optimize existing ones. Autopol has features for stability analysis, sequence optimization, and structure prediction.
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opensource protein-engineering protein-design stability-analysis sequence-optimization structure-prediction

Autopol: Open-Source Protein Engineering Tool

Autopol is an open-source tool for computer-aided protein engineering and protein design, allowing users to computationally design novel proteins and optimize existing ones with features for stability analysis, sequence optimization, and structure prediction.

What is Autopol?

Autopol is an open-source software tool developed for computer-aided protein engineering and computational protein design. It provides a suite of algorithms and methods to help users design novel protein sequences and optimize existing proteins.

Some of the key features and capabilities of Autopol include:

  • Protein stability analysis - Calculate and predict thermodynamic stability changes upon mutation using empirical force fields and statistical potentials.
  • Sequence optimization - Computationally optimize protein sequences for improved stability, expression, solubility, and other properties using various search algorithms.
  • Structure prediction - Model and predict 3D protein structure from sequence using comparative modeling, threading, and ab initio structure prediction protocols.
  • Design ability - Design completely novel proteins and protein-protein interactions not found in nature by optimizing sequences to fold into target structures.
  • Intuitive graphical interface - Allows users to set up protein design projects, run calculations, and analyze results easily through the graphical user interface.
  • Customizable workflows - Flexible python pipelines make it easy for users to set up and control customized protein engineering workflows.

Overall, Autopol simplifies and streamlines computer-aided protein design and engineering by integrating state-of-the-art algorithms into a single open-source framework. It enables both experts and non-experts to harness computational power for optimizing proteins and designing new ones suitable for a wide range of downstream applications.

Autopol Features

Features

  1. Sequence optimization
  2. Stability analysis
  3. Structure prediction
  4. Protein engineering
  5. Protein design

Pricing

  • Open Source

Pros

Open source

User friendly interface

Active development community

Comprehensive toolset for protein engineering

Cons

Limited documentation

Steep learning curve

Not as robust as some commercial alternatives


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